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Their therapeutic use for prevention of cardio-embolic difficulties was validated in the latest big period III trials, demonstrating their non-inferiority, and even superiority, in certain scenarios, to warfarin [5,6,7].PLOS One particular | DOI:ten.1371/journal.pone.0126512 Could fourteen,2 /Efficacy and Safety of NOACs in RFCA of AFTherefore, use of NOACs is now recommended by guidelines, in add