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Their therapeutic use for prevention of cardio-embolic difficulties was validated in new significant section III trials, demonstrating their non-inferiority, and perhaps superiority, in a few circumstances, to warfarin [5,six,7].PLOS 1 | DOI:10.1371/journal.pone.0126512 Could fourteen,two /Efficacy and Protection of NOACs in RFCA of AFTherefore, usage of NOACs is presently advised by suggestions,