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Their therapeutic use for prevention of cardio-embolic issues was validated in the latest significant phase III trials, demonstrating their non-inferiority, and even superiority, in some conditions, to warfarin [5,6,7].PLOS A person | DOI:ten.1371/journal.pone.0126512 May possibly 14,two /Efficacy and Security of NOACs in RFCA of AFTherefore, use of NOACs is now suggested by suggestions, along wit