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S been studied extensively for hydrogenase 3 from E. coli by Bock and colleagues in Munich and has been reviewed ?(226, 228). The concentration of H2 in cells is sensed by hupUV gene products, which in other organisms are termed HoxBC. These proteins also catalyze the cleavage of H2 and can therefore be considered an independent, regulatory hydrogenase, e.g., in Ralstonia eutropha (79). HYDROGENAS